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A cell communicates by what it releases. That entire output is called the secretome. The secretome includes everything a cell secretes: • Growth factors • Cytokines • Enzymes • Lipids • Metabolic signals • Exosomes Most of those signals are: • Free-floating • Short-lived • Local • Quickly degraded They matter, but they don’t last. Exosomes are different. Exosomes are a specific, powerful subset of the secretome: • Nano-sized, lipid-sealed packages • Loaded with proteins and genetic instructions
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