Acute Ischemic Stroke Treatment | TNKase® (tenecteplase)
Tenecteplase is an enzyme that, when present in blood in pharmacologic concentrations, remains active under in vitro conditions. This can lead to degradation of fibrinogen in blood samples removed for …
TNK stroke treatment: How it works, administration, and more
Oct 1, 2024 · Tenecteplase (TNK) can help dissolve blood clots to treat acute ischemic stroke. Learn about how it works, when doctors administer it, and more.
TNK vs tPA — The ORIGINAL Trial - REBEL EM - Emergency Medicine …
May 5, 2025 · Several studies have demonstrated the safety and efficacy of TNK as an alternative to tPA.3–10. The ORIGINAL trial evaluated the noninferiority of TNK compared to tPA in Chinese …
Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without ...
Jun 14, 2024 · Tenecteplase is an effective thrombolytic agent for eligible patients with stroke who are treated within 4.5 hours after the onset of stroke. However, data regarding the effectiveness of...
Tenecteplase Uses, Side Effects & Warnings - Drugs.com
Oct 28, 2025 · Tenecteplase is used in adults to treat a stroke caused by a clot (acute ischemic stroke) and to lower the risk of death from a certain type of heart attack. Tenecteplase may also be used for …
TNK Injection: Uses & Side Effects - Cleveland Clinic
TNK (tenecteplase) dissolves blood clots in certain blood vessels in your body. Blood clots happen when your blood thickens.
The Effectiveness of TNK as a Treatment for Strokes
Jan 29, 2026 · Covenant Health is proud to be the region’s only stroke-certified hospital network, using the most effective stroke treatments to promote better outcomes. Our network has adopted …
Intra-arterial Tenecteplase for Acute Stroke After Successful ...
Jul 5, 2025 · Building on previous clinical experience, the ANGEL-TNK trial restricted the use of periprocedural antithrombotic drugs via defined inclusion and exclusion criteria.
What is Tenecteplase (TNKase)? Tenecteplase (TNKase) is a protein that can break up blood clots. It is a medication administered to patients experiencing a stroke caused by a sudden blockage by a …
Food and Drug Administration Approval of Tenecteplase: What This …
It was not until 2023 that Genentech began discussions with the US Food and Drug Administration (FDA) for approval of TNK for AIS. On February 28, 2025, based in particular on the design and …