Pigment epithelium-derived factor (PEDF) also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has anti-angiogenic, anti- tumorigenic, and neurotrophic …

The present review summarizes the temporal and spatial distribution patterns of PEDF in a variety of developing and adult organs, and discusses its functions in maintaining physiological …

Pigment epithelium-derived factor (PEDF) is defined as an endogenously produced 50 kDa glycoprotein that exhibits neurotrophic, neuroprotective, cell differentiating, antitumour, and …

Aug 1, 2003 · Pigment epithelium-derived factor (PEDF) is a molecule with neurotrophic, neuroprotective and antiangiogenic properties. It is structurally related to the serpin family of …

Jul 21, 2025 · This review highlights recent findings on the potent anti-angiogenic serpin protein, pigment epithelium-derived factor (PEDF) as it relates to metabolic disease, diabetes, …

PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body.

Sep 1, 2022 · Pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, exerts antiangiogenic effects without affecting the structure and function of normal blood vessels. …

Jun 18, 2025 · The functions of PEDF are pronounced within the eye, where its anti-angiogenic capabilities are important for maintaining retinal health. As a potent inhibitor of abnormal blood …

PEDF is one of the most abundant adipokines and its secretion is inversely regulated by insulin and hypoxia. PEDF induces insulin resistance in adipocytes and hSkMC and leads to …

Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that is widely expressed throughout the human body, and exhibits multiple and varied biological activities.