DTT is used as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolated DNA have a tendency to form dimers in solution, especially in the presence of oxygen.

Thermo Scientific DTT (DL-Dithiothreitol; Clelands reagent) is used to stabilize enzymes and other proteins, which possess free sulfhydryl groups. It has been shown to restore activity lost by oxidation …

Whereas chemical methods are not reliable for detecting and measuring DTT in biologic fluids, preliminary evidence indicates that a silylated derivative of oxidized DTT can be detected in the urine …

DTT operates through thiol-disulfide exchange reactions. It possesses two thiol (-SH) groups that can donate electrons to disulfide bonds (S-S) in proteins, reducing them to free thiol groups.

Dithiothreitol (DTT) is extensively applied in chemical peptide synthesis and biochemical preparations of thiol proteins. It is also used in protein chemistry studies, such as protein folding and enzyme activity. …

Dithiothreitol (DTT) is a reducing agent that can reduce the expression of CD38 on red blood cells, enabling further investigation while also potentially affecting the expression of other clinically …

A staple of biochemistry and protein labs, dithiothreitol (DTT) was introduced in 1963. Less volatile and less odorous than the commonly used thiol β-Mercaptoethanol, DTT is a highly efficient and versatile …

DTT is frequently used to reduce the disulfide bonds of proteins and peptides. It prevents intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins.

DTT is used as a reducing or "deprotecting" agent for thiolated DNA. The terminal sulfur atoms of thiolated DNA have a tendency to form dimers in solution, especially in the presence of oxygen.

We often get questions about DTT regarding solution preparation, storage, stability, handling, trouble shooting, and how to avoid common mistakes. Here are the most frequently asked questions we …