Engineers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Researchers have used artificial intelligence to design ionizable lipids that outperform current gold-standard molecules in delivering mRNA, a key technology in vaccines and gene therapies. The ...

Just as a chef perfects a dish by experimenting with flavors and textures, the researchers used an iterative process, testing variations to find the ideal structure for the ionizable lipid. This lipid ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Finally, when the team used the C-a16 lipids for preparing COVID-19 mRNA vaccines, the immune response in animal models was five times stronger than with standard formulations. "By causing less ...

Lipid nanoparticles have become the workhorse of mRNA vaccines, ferrying genetic cargo into cells so the immune system can learn to recognize a threat. But most LNPs don’t travel where vaccine ...

A team from the Max-Planck-Institut für Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle differences in molecular structure can have a major impact on the ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...

Better mRNA release inside cells boosts vaccine and gene editing performance, enabled by redesigned lipid molecules that grip cargo tightly but let go quickly once inside cells. For vaccines, this was ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...