Left: In the dentate gyrus of the hippocampus of 4-5 month-old Rp58 heterozygous-KO mice, DNA damage accumulates in the mossy cells (yellow-green) (ssDNA; red), and the surrounding microglia (blue) ...
A mouse line with severe haploinsufficiency of about 92% reduction in coiled-coil and C2 domain-containing protein 1A (CC2D1A) expression was generated by breeding of Cc2d1a-knockout allele with C2d1a ...
This is a knock-in (KI) mouse model carrying a L444P mutation in the endogenous Gba (glucocerebrosidase [GC] or acid β-glucosidase) gene (Liu et al., 1998). The GBA1 protein is the lipid-degrading ...
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