Designing Transition-State Inhibitors A transition-state mimic has the power to bind an enzyme at its tipping point as strongly as any available inhibitor and more strongly than most, preventing ...
Boronic acid inhibitors restore cefepime efficacy in multidrug-resistant KPC-producing K. pneumoniae
The boronic acid transition state inhibitors S-02030 and MB-076 were strategically designed to be active against cephalosporinases and carbapenemases, especially KPC (Klebsiella pneumoniae ...
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