Researchers at the University of California, Irvine, and MIT are taking a novel approach to preventing and treating bacterial infections. Like people, bacteria need iron. The problem is that soluble ...

Siderophores are specialised, high‐affinity iron chelators secreted by bacteria to secure the essential metal from often iron‐limited environments. Their biosynthesis is intricately controlled via two ...

This discovery validates siderophore secretion as a drug target in tuberculosis and reveals a new mechanism for putative drugs. Many tuberculosis bacteria are highly resistant to multiple antibiotics.

Please provide your email address to receive an email when new articles are posted on . Multidrug-resistant (MDR) gram-negative bacteria continue to present an important threat to public health, and a ...

Pathogen virulence is often mediated by cooperative traits (see West et al., 2006 and references therein). Thus, understanding the evolution and ecology of cooperation in pathogenic microbes not only ...

A new drug conjugate tricks Gram-negative bacteria into succumbing to an antibiotic that usually works only against Gram-positive bacteria. Gram-negative bacterial infections are tough to treat ...

The Centers for Disease Control and Prevention warned last fall that the U.S. faces "potentially catastrophic consequences" if it doesn't act quickly to combat the growing threat of ...

RTI International has divulged vancomycin derivatives with siderophore modification reported to be useful for the treatment of gram-negative and gram-positive bacterial infections.