The Escherichia coli chromosome encodes toxin-antitoxin pairs. The toxin RelE cleaves mRNA positioned at the A-site in ribosomes, whereas the antitoxin RelB relieves the effect of RelE. The ...
Prokaryotic toxin–antitoxin (TA) loci, such as relBE and mazEF, encode mRNA-cleaving enzymes that are activated by nutritional stress. Slowly growing bacteria and Archaea have numerous TA loci. For ...
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