Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding where ...

Cold Spring Harbor Laboratory’s Cifani lab has developed a new mass spectrometry technique that pushes the performance of ...

The analytical workflow begins with the separation of the complex protein mixture, often utilizing liquid chromatography (LC) or capillary electrophoresis (CE) coupled directly to the MS system.

As our bodies run multiple parallel processes, they shuttle a flurry of messages around inside—often as protein-metabolite interactions (PMIs), where small molecules bind to a protein and initiate or ...

Proteomics is the large-scale study of proteins, particularly their structures and functions. It involves the systematic identification, quantification, and analysis of the entire protein complement ...

To identify specific chemicals or molecules in the life sciences and medical research, scientists often use mass spectrometry (MS), usually paired with liquid chromatography (LC). These technologies ...

Cold Spring Harbor Laboratory's advanced mass spectrometry method enhances sensitivity, facilitating better drug target ...

A disassembled charge-detection mass spectrometry ion trap. A disassembled charge detection mass spectrometry ion trap Credit: Gwendolyn Jarrold At the University of Oxford, Justin Benesch studies ...

Those hoping to uncover new science may feel disheartened if they struggle with inadequate tools and doubt that more capable tools are within reach. Until recently, such was the case in proteomics.