Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Neurodegenerative diseases, such as Parkinson’s or Alzheimer’s, are associated with the deposition of protein aggregates in the brain. These aggregates accumulate when the cellular waste removal ...

Researchers at Baylor College of Medicine have discovered a potential new strategy to fight back against Alzheimer's and Parkinson's diseases, conditions that are linked to the toxic accumulation of ...

Tubulin acts as a master regulator, preventing Tau and alpha-synuclein from forming toxic clumps in Alzheimer's and Parkinson's.

PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

Intracellular proteins that condense into droplets via liquid-liquid phase separation (LLPS) have been suspected of favoring the formation of amyloid fibrils, and thereby causing neurodegenerative ...

The causes of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia and prion diseases can be many and varied. But there is a common denominator, namely ...

A new study from Aarhus University shows that our cells' ability to clean out old protein clumps, known as aggregates, also includes a—up till now unknown—partnership with an engine that breaks down ...

Protein misfolding and aggregation are key features observed in numerous neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. The oligomers formed during the aggregation process ...

Loss and dysfunction of synapses have been linked to age-related cognitive decline and observed in Alzheimer's and other ...

Researchers have identified a natural compound from pomegranate leaves and branches that can directly dismantle the protein aggregates responsible for transthyretin amyloidosis.