MultiPerturb-seq captures changes in chromatin and RNA states driven by CRISPR perturbations. Yan et al. identify perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells ...

Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Firefly Bio seeks to improve on antibody–drug conjugates and proteolysis-targeting ...

An illustration of lipid nanoparticles (green circles) targeting the lung, designed using neural networks. Witten et al. present a method (LiON) using neural networks for lipid discovery and ...

Nguyen et al. developed a lyophilized synthetic biology circuit embedded in fabric that transmits viral detection signals through a textile-integrated waveguide. See Nguyen et al. Image: Peter Q.

Single-cell proteomics maps protein dynamics in the developing human brain.

Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1 agonists while avoiding muscle ...

Wearable sensors are evolving to provide accurate, continuous and wireless monitoring of our health and disease states. Using designs and materials that interface seamlessly with skin, accessing a ...

Optimizing guide RNA design for Cas13. With data from massively parallel screens, Wessels et al. develop computational models to identify optimal guide RNAs for the RNA-targeting CRISPR enzyme Cas13d.

A series of bright fluorescent RNAs enable imaging of RNA in live cells. This original image shows heterogeneity of protein translation in a cancer cell line, where mCherry protein (red) and its ...

Scanning electron micrograph of a heart-forming organoid showing a myocardial layer (pink) separated by a thin endocardial layer (blue) from an anterior foregut endoderm and vascular layer (cinnamon); ...

Hand-painted picture of a rice plant, showing the extensive root system. Zhang et al. show that rice recruits specific bacteria to the root microbiota to optimize nitrogen acquisition from soil. See ...

Staircase inspired by a DNA spiral in the BC Cancer Agency Research Centre (Vancouver, BC, Canada). This issue brings together articles focused on DNA sequencing ...