Three years after launching from the lab of University of California, San Francisco chemist Jim Wells, the start-up EpiBiologics has raised $109 million in series B funding to propel its ...
The intricate regulation of receptor tyrosine kinases (RTKs) underpins a vast array of cellular responses that are essential for growth, differentiation and survival. In particular, the interplay ...
Signal transduction by GRB2 and SOS1. When some substances bind to a membrane receptor, a reaction occurs between the receptor and GRB2, which then goes on to bind and activate SOS1. SOS1 can then ...
GPCRs (G-protein-coupled receptors) represent the largest family of membrane receptors currently targeted by approved drugs. It is estimated that approximately 700 approved drugs target GPCRs ...
A revolution has occurred in the field of pharmaceutical development due to the development of drugs that target membrane proteins. It is estimated that one-third of currently available drugs target G ...
The Warburg effect describes how cancer cells switch from oxidative phosphorylation to glycolysis even in oxygen-rich ...
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