Leptin, a hormone secreted by adipose tissue, communicates body fat stores to the brain and orchestrates appetite, energy expenditure and neuroendocrine function. Binding of leptin to its long-form ...
Obesity has become a global epidemic, and the need for treatment and monitoring for people with obesity is growing. Researchers aiming to understand relevant biomarkers for the condition have fixed ...
Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...
Leptin is a peptide hormone secreted primarily by adipocytes that informs the central nervous system about energy stores and regulates appetite and metabolism. In rare cases, pathogenic variants in ...
Researchers have successfully treated two unrelated children with characteristics of leptin dysfunction — including intense hyperphagia, impaired satiety, and severe, early onset obesity — only after ...
Among adults with hypertension and overweight or obesity, a 16-week supervised aerobic exercise program combined with a hypocaloric diet reduced leptin levels more than a hypocaloric diet plus ...
Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...
The exact mechanisms underlying leptin resistance remain elusive. Here, Wang et al. report that adipocyte-derived EVs and their miRNA cargo are key regulators of central leptin sensitivity and that ...
A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged ...
Obesity affects a staggering 40 percent of adults and 20 percent of children in the United States. While some new popular therapies are helping to tackle the epidemic of obesity, there is still so ...
The risk of early-onset breast cancer, particularly luminal A and triple-negative subtypes, was higher in Black women with obesity and high leptin levels compared with White women. This research ...
Reduced availability of leptin, a hormone that helps you maintain a healthy weight by regulating your appetite and helping to maintain energy balance, has been found to play a role in the development ...
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