The combination of digital pathology with immunohistochemistry is helping to resolve a major issue that has until now limited the accuracy and reliability of the immunohistochemical technique. In a ...

In immunohistochemistry, colored substrates are used to detect specific proteins within a biological sample. For example, after application of the primary antibody, a second antibody conjugated to an ...

Immunohistochemistry plays a key role in the diagnosis of soft tissue tumors. Until recently, however, the primary purpose of immunohistochemistry in this context was simply to attempt to demonstrate ...

High-risk human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas have a more favorable prognosis than HPV-negative ones. p16 immunohistochemistry has been recommended as a ...

A retrospective, cross-sectional study analyzed national trends of immunohistochemistry (IHC) use in the diagnosis of melanoma. Immunohistochemistry (IHC) has emerged as a clinical tool in skin ...

Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer Jennet M. Harvey Gary M. Clark C. Kent ...

Three programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for treatment of non–small-cell lung cancer (NSCLC). Treatment with pembrolizumab in NSCLC requires PD-L1 ...

Three-dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues. However, traditional methods are often ...

Researchers from Lund University (Sweden) have investigated the tumor immune microenvironment of primary triple-negative breast cancer using digital image analysis of IHC-stained immune cells. To do ...

Immunohistochemistry (IHC) is a special test used by pathologists to detect specific molecules on cells. It is widely used in clinical oncology for categorizing solid cancer tumors and blood cancers, ...