A cell-free genomics approach silences cellular noise and reveals transcription drivers, improving our understanding of a ...

Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells. What determines these differences? It all comes down to gene ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor ...

In a new study published in Cell Reports, researchers at the University of Freiburg detail how a disordered protein fragment connects two key stages of gene expression: transcription and RNA editing.

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated ...

The human genome contains about 23,000 genes, but only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression ...

To support drug discovery, a new study has revealed fundamental features of the transcription cycle in the bacteria that causes tuberculosis.

A newly released publication examines how deuterium concentration may influence gene activity in lung cancer cells. The study explores how shifts in this ...

Timing of gene expression Demonstrating their technique in mouse embryonic stem cells, the researchers found that they could calculate approximately when a particular region starts to be transcribed, ...