Peptide-based signaling systems continue to occupy a central role in modern biochemical inquiry, particularly in areas concerned with extracellular matrix (ECM) dynamics and structural protein ...

Estrogen loss in aging females causes the collapse of the brain's extracellular matrix, increasing Alzheimer's risk.

Aging-related cognitive decline is an early symptom of Alzheimer's disease and other dementias, and on its own can have substantial consequences on an individual's ability to perform important ...

The basement membrane is a specialised form of extracellular matrix that underlies epithelial and endothelial cell layers, forming a thin yet robust scaffold composed primarily of laminins, type IV ...

A largely overlooked space between cells in women's brains may hold the key to understanding memory loss tied to estrogen decline after menopause, reports a new preclinical Northwestern Medicine study ...

This is the first study of its kind to examine this part of the brain and its link to estrogen.

In a recent study, led by corresponding author, Anna-Maria Liphardt, PhD, of the Rheumatology and Immunology Department at Friedrich-Alexander-Universität Erlangen-Nürnberg and the ...

Researchers found that localized estrogen loss in the brain caused memory and social impairments in aging female mice. The ...