By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes long-standing trade-offs between maximizing expression metrics and maintaining ...

Combining MAGE with CAGE allowed the genome to manipulated as an editable and evolvable template. Scientists have combined a recently developed technique known as multiplex automated genome ...

Codon-optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. It is used extensively for expressing recombinant protein drugs, gene therapy ...

An illustration of E. coli. Scientists have been racing to shrink the genetic code of this bacterium. Kateryna Kon / Science Photo Library via Getty Images The DNA of nearly all life on Earth is made ...

We have gone further than ever before in creating life that is unlike anything that has evolved naturally. The genome of an Escherichia coli bacterium has been redesigned on a computer to use just 57 ...

A study conducted by researchers at Ohio State University and the New York University Grossman School of Medicine in the USA, has revealed that optimization of codon for bacterial expression causes ...

The DNA of nearly all life on Earth contains many redundancies, and scientists have long wondered whether these redundancies served a purpose or if they were just leftovers from evolutionary processes ...

Firm reports in PLoS ONE the identification of codon-choice design principles that allow greater protein expression. DNA2.0 reports that is has figured out how to chose codons that will optimize ...

The DNA of nearly all life on Earth is made up of 64 codons, each one a sequence of three nucleotide bases, the building blocks of DNA. These codons contain instructions for building amino acids, ...