Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells.

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

Once disregarded as “junk DNA,” scientists now know that this molecular dark matter is crucial for determining gene activity ...

Epigenetic modifications such as DNA methylation play a key role in regulating gene expression. Emerging evidence suggests ...

Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

By Tarun Sai Lomte Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s ...

Researchers found how the INO80 protein moves nucleosomes to specific positions that are important for gene regulation and DNA replication INO80 uses a unique mechanism for moving nucleosomes that ...

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...