T cells are supposed to be relentless. These white blood cells patrol the body, identify threats, and destroy them.

Developing the system required careful fine-tuning. Too much stimulation can wear out immune cells, while too little allows them to lose function. The researchers optimized the strength of activation ...

By Sheena Cruickshank, University of Manchester and Jonathan Worboys, for The ConversationA new immunotherapy drug has demonstrated early promise in a recent prostate cancer clinical trial. The drug, ...

Commercialization ready compound supports a new method of generating highly functional human CAR-T cells for treating infectious diseases and ...

Immunotherapy has transformed cancer treatment by harnessing the body's own immune system to fight disease. But many engineered immune cells lose strength quickly after they enter the body, especially ...

Tumour reactive T cells identified through transcriptional profiling predict response to multiple myeloma immunotherapy and track treatment activity.

An experimental immunotherapy drug called VIR-5500 has driven prostate-specific antigen (PSA) levels down by as much as 99% in some men with metastatic castration-resistant prostate cancer, according ...

A naturally occurring byproduct of liver metabolism—the ketone body, β-hydroxybutyrate (BHB)—can strengthen the fitness and antitumor activity of CAR T cells. The findings, reported on March 6, 2026 ...

HOUSTON -- Patients with advanced or refractory cutaneous T-cell lymphoma (CTCL) achieved near-100% disease control with single-agent immunotherapy or an immuno-oncology (IO) combination, a small ...

Treating the brain cancer glioblastoma (GBM) demands more than conventional strategies due to a mix of factors including the cancer’s genetic complexity, invasive growth, and immune resistance. A new ...