This image depicts the detection of structural variants (SVs) at low sequencing coverage in both unique and repetitive regions by genomic proximity mapping (GPM), compared with other SV-calling ...

Chinese researchers have developed a groundbreaking technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis.

University of Wisconsin researchers Sushmita Roy and Erika Da-Inn Lee have developed a new computational tool that maps changes in the genome, ultimately helping researchers see DNA’s 3D organization ...

In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed maps to date ...

The genome is more than a linear code; it is a dynamic structure whose three-dimensional folding dictates how genes are regulated. Traditional sequencing technologies capture base-level variation but ...

Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Two new studies uncover how DNA folding controls sperm cell development. Researchers identified proteins that rearrange genomic architecture, setting cellular memory and fate. This 3D genome mapping ...

Before cells can divide by mitosis, they first need to replicate all of their chromosomes, so that each of the daughter cells can receive a full set of genetic material. Scientists have until now ...

Every time we step outside, our cells are exposed to ultraviolet (UV) radiation, which is known to cause deoxyribonucleic acid (DNA) damage. While our bodies have built-in repair mechanisms to undo ...